Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers

by G.O. Evans
July 2008

Hematology data from in vivo toxicology studies remains one of the most predictive measures for human risk, as the same measurements made in pre-clinical toxicology studies can be made in early clinical trials.

Covering the three main blood cell types – erythrocytes, leukocytes and thrombocytes, this work is designed to clarify topics for new entrants to the fields of laboratory animal hematology and toxicology, especially those topics where the rules for human hematology do not always apply. An entire chapter is devoted to immunotoxicology, a scientific discipline that is closely aligned with hematology.

The text also addresses pre-analytical and analytical variables that affect animal studies, as these play a far more important part when interpreting data in contrast to humans where many of these variables can be well controlled or have less physiological effect. Information has been collated from published papers, textbooks and unpublished data: Readers are provided with key references to encourage further study

• Covers a full range of the discipline, from basic principles to diagnostic evaluation, in a clear and concise manner
• Provides information on main laboratory animal species with tables of reference values
• Includes a chapter on bone marrow evaluation containing material on micronucleus tests in genetic toxicology
• Explores differences in cell counting techniques
• Contains a chapter on immunotoxicology